Key Dates

Related Announcements

PA-19-056 - NIH Research Project Grant (Parent R01 Clinical Trial Not Allowed)

PA-18-480 - NICHD Research Project Grant (R01 Clinical Trial Required)

PA-18-481 - NICHD Small Grant Program (R03 - Clinical Trial Optional)

PA-18-482 - NICHD Exploratory/Developmental Research Grant (R21 - Clinical Trial Optional)

PA-19-272 - PHS 2019-02 Omnibus Solicitation of the NIH, CDC, and FDA for Small Business Innovation Research Grant Applications (Parent SBIR [R43/R44] Clinical Trial Not Allowed)

PA-19-273 - PHS 2019-02 Omnibus Solicitation of the NIH, CDC, and FDA for Small Business Innovation Research Grant Applications (Parent SBIR [R43/R44] Clinical Trial Required)

PA-19-270 - PHS 2019-02 Omnibus Solicitation of the NIH for Small Business Technology Transfer Grant Applications (Parent STTR [R41/R42] Clinical Trial Not Allowed)

PA-19-271 - PHS 2019-02 Omnibus Solicitation of the NIH for Small Business Technology Transfer Grant Applications (Parent STTR [R41/R42] Clinical Trial Required)

PA-18-817 - Administrative Supplements for Research on Dietary Supplements (Admin Supp - Clinical Trial Not Allowed

Issued by

Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD )

Purpose

Iodine is an essential nutrient that must be obtained via the food supply in order to meet established requirements for health. Despite a long and evolving history of understanding with regard to the impact of iodine deficiency, meeting iodine requirements remains a domestic and global challenge. Because of its key role in human development, adequate iodine nutrition of men and women of reproductive age, women during pregnancy and lactation, and infants and children is a critical public health priority. Despite significant progress in terms of public health programs and interventions, significant gaps remain to be filled in order to fully inform these efforts, particularly with regard to our understanding of the biology, assessment, and outcomes of iodine status in these groups.

This Notice will encourage research using a range of disciplines and approaches to address the gaps in our understanding of the biology and functional impact of iodine nutrition, and in particular, mild-to- moderate iodine deficiency in men and women of reproductive age (including women during adolescence, pregnancy, and lactation) as well as in infants and children. Studies across the age spectrum and in various demographic (sex/ethnic/racial) subgroups are of interest as well.

Topics of Interest

This Notice is intended to stimulate research to address critical gaps in our understanding of iodine nutrition, assessment, and status-related outcomes (with an emphasis on mild-to-moderate dietary insufficiency). Topics of interest include, but are not necessarily limited, to:

• Mechanistic and proof-of-concept studies of dose-response relationships and other questions, which could lead to:
  • Enhanced understanding of relevant biological pathways
  • Identification of sensitive and specific biomarkers of iodine status
  • Identification of bio-indicators of relevant functional outcomes
  • Enhanced understanding of iodine nutritional requirements
• Cross-sectional and longitudinal cohort studies identifying iodine status, with participants drawn from the general population and at-risk groups
• Efficacy and effectiveness trials of iodine supplementation
• Resources and tools for research, public health practice, and clinical use, including:
  • Systems biology approaches (including relevant -omics technologies)
  • Laboratory-oriented approaches (including chemical analytic methodology)
  • Biological sample needs and storage challenges (e.g., blood, urine, human milk, etc.)
  • Assessment of dietary iodine exposure
  • Test diets for both basic and clinical study
  • Reference standards and certified reference materials
  • Point-of-care devices for iodine assessment
  • Statistical- and data-oriented materials and methodology (including questionnaires and behavioral and developmental assessment tools)
  • Sampling surveys of foods, dietary supplements, and other materials from retail, wholesale, and other settings

Application and Submission Information

This notice applies to due dates on or after January 5, 2020 and subsequent receipt dates through January 8, 2022.

Submit applications for this initiative using one of the following funding opportunity announcements (FOAs) or any reissues of these announcement through the expiration date of this notice.

• PA-19-056 - NIH Research Project Grant (Parent R01 Clinical Trial Not Allowed)
• PA-18-480 - NICHD Research Project Grant (R01 Clinical Trial Required)
• PA-18-481 - NICHD Small Grant Program (R03 Clinical Trial Optional)
• PA-18-482 - NICHD Exploratory/Developmental Research Grant (R21 Clinical Trial Optional)
• PA-19-272 - PHS 2019-02 Omnibus Solicitation of the NIH, CDC, and FDA for Small Business Innovation Research Grant Applications (Parent SBIR [R43/R44] Clinical Trial Not Allowed)
• PA-19-273 - PHS 2019-02 Omnibus Solicitation of the NIH, CDC, and FDA for Small Business Innovation Research Grant Applications (Parent SBIR [R43/R44] Clinical Trial Required)
• PA-19-270 - PHS 2019-02 Omnibus Solicitation of the NIH for Small Business Technology Transfer Grant Applications (Parent STTR [R41/R42] Clinical Trial Not Allowed)
• PA-19-271 - PHS 2019-02 Omnibus Solicitation of the NIH for Small Business Technology Transfer Grant Applications (Parent STTR [R41/R42] Clinical Trial Required)
• PA-18-817 - Administrative Supplements for Research on Dietary Supplements (Admin Supp - Clinical Trial Not Allowed)

All instructions in the SF424 (R&R) Application Guide and the funding opportunity announcement used for submission must be followed, with the following additions:

• For funding consideration, applicants must include “NOT-HD-19-039” (without quotation marks) in the Agency Routing Identifier field (box 4B) of the SF424 R&R form. Applications without this information in box 4B will not be considered for this initiative.

Inquiries

Scientific/Research Contact(s)

Daniel J. Raiten, PhD
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Telephone: 301-435-7568
Email: raitend@mail.nih.gov

Abby G. Ershow, ScD
NIH Office of Dietary Supplements
Telephone: 301-435-2920
Email: abby.ershow@nih.gov