[Federal Register Volume 84, Number 218 (Tuesday, November 12, 2019)]
[Notices]
[Pages 61057-61058]
From the Federal Register Online via the Government Publishing Office [www.gpo.gov]
[FR Doc No: 2019-24465]
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DEPARTMENT OF HEALTH AND HUMAN SERVICES
Centers for Disease Control and Prevention
[CDC-2019-0093; NIOSH-156-E]
Request for Information for Six Chemicals To Develop Immediately
Dangerous to Life or Health (IDLH) Values.
AGENCY: National Institute for Occupational Safety and Health (NIOSH)
of the Centers for Disease Control and Prevention (CDC), Department of
Health and Human Services (HHS).
ACTION: Request for information.
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SUMMARY: The National Institute for Occupational Safety and Health
(NIOSH) of the Centers for Disease Control and Prevention (CDC) intends
to evaluate the scientific data for 6 chemicals--allyl alcohol, bromine
chloride, hydrogen bromide, hydrogen iodide, lewisite (a chemical
warfare agent), and propylene imine--to develop new or updated
Immediately Dangerous to Life or Health (IDLH) values.
DATES: Electronic or written comments must be received by January 13,
2020.
ADDRESSES: You may submit comments, identified by CDC-2019-0093 and
Docket Number NIOSH-156-E, by either of the two following methods:
Federal eRulemaking Portal: http://www.regulations.gov.
Follow the instructions for submitting comments.
Mail: NIOSH Docket Office, Robert A. Taft Laboratories,
MS-C34, 1090 Tusculum Avenue, Cincinnati, OH 45226.
Instructions: All information received in response to this notice
must include the agency name and docket number (CDC-2019-0093; NIOSH-
156-E). All relevant comments received will be posted without change to
http://www.regulations.gov, including any personal information
provided. All electronic comments should be formatted in Microsoft
Word. Please make reference to CDC-2019-0093 and Docket Number NIOSH-
156-E.
FOR FURTHER INFORMATION CONTACT: R. Todd Niemeier, MS, NIOSH, MS-C32,
1090 Tusculum Avenue, Cincinnati, OH 45226, telephone (513) 533-8166.
SUPPLEMENTARY INFORMATION: In 2013, NIOSH published Current
Intelligence Bulletin (CIB) 66--Derivation of Immediately Dangerous to
Life or Health (IDLH) Values [http://www.cdc.gov/niosh/docs/2014-100/pdfs/2014-100.pdf] [NIOSH 2013]. The information presented in this CIB
represents the most recent update of the scientific rationale and the
methodology (hereby referred to as the IDLH methodology) used to derive
IDLH values. Since the establishment of the IDLH values in the 1970s,
NIOSH has continued to review available scientific data to improve the
protocol used to derive acute exposure guidelines, in addition to the
chemical-specific IDLH values.
IDLH values are based on health effects considerations determined
through a critical assessment of the toxicology and human health
effects data. This approach ensures that the IDLH values reflect an
airborne concentration of a substance that represents a high-risk
situation that may endanger workers' lives or health.
The primary steps applied in the establishment of an IDLH value
include the following:
1. Critical review of human and animal toxicity data to identify
potentially relevant studies and characterize the various lines of
evidence that can support the derivation of the IDLH value;
2. Determination of a chemical's mode of action (MOA) or
description of how a chemical exerts its toxic effects;
3. Application of duration adjustments (time scaling) to determine
30-minute-equivalent exposure concentrations and the conduct of other
dosimetry adjustments, as needed;
4. Experimental or other data to establish a point of departure
(POD) such as lethal concentrations (e.g., LC50), lowest observed
adverse effect level (LOAEL), or no observed adverse effect level
(NOAEL);
5. Selection and application of an uncertainty factor (UF) for POD
or critical adverse effect concentration, identified from the available
studies to account for issues associated with interspecies and
intraspecies differences, severity of the observed effects, data
quality, or data insufficiencies; and
6. Development of the final recommendation for the IDLH value from
the various alternative lines of evidence, with use of a weight-of-
evidence approach to all of the data.
NIOSH seeks to obtain materials, including published and
unpublished reports and research findings, to evaluate the possible
acute health risks of occupational exposure to the following six
chemicals:
1. Allyl Alcohol (CAS# 107-18-6)
2. Bromine Chloride (CAS# 13863-41-7)
3. Hydrogen Bromide (CAS# 10035-10-6)
4. Hydrogen Iodide (CAS# 10034-85-2)
5. Lewisite (a chemical warfare agent) (CAS#s 541-25-3, 40334-69-8,
40334-70-1)
6. Propylene Imine (CAS# 75-55-8)
Materials also include reports of acute animal toxicity studies,
acute human toxicology studies, mode of action studies, and other
information about a chemical's toxic effects such as studies on sensory
or respiratory irritation, nervous system effects (e.g., dizziness,
central nervous system excitability, autonomic effects, muscle tone/
equilibrium effects, sensorimotor reactivity, nervous system
histopathology), metabolic toxicants, target organ toxicants,
gastrointestinal effects, cardiovascular changes, and asphyxiants.
[[Page 61058]]
In a subsequent notice, Draft IDLH Value profiles for these
chemicals will be made available for public comment.
Reference
NIOSH [2013]. Current intelligence bulletin 66: derivation of
immediately dangerous to life or health (IDLH) values. Cincinnati, OH:
US Department of Health and Human Services, Centers for Disease Control
and Prevention, National Institute for Occupational Safety and Health,
DHHS (NIOSH) Publication 2014-100.
John J. Howard,
Director, National Institute for Occupational Safety and Health,
Centers for Disease Control and Prevention.
[FR Doc. 2019-24465 Filed 11-8-19; 8:45 am]
BILLING CODE 4163-18-P