Award Abstract # 2026944
RAPID: On-mask Chemical Modulation of Respiratory Droplets

NSF Org: DMR
Division Of Materials Research
Recipient: NORTHWESTERN UNIVERSITY
Initial Amendment Date: March 17, 2020
Latest Amendment Date: March 17, 2020
Award Number: 2026944
Award Instrument: Standard Grant
Program Manager: Birgit Schwenzer
bschwenz@nsf.gov
 (703)292-4771
DMR
 Division Of Materials Research
MPS
 Direct For Mathematical & Physical Scien
Start Date: April 1, 2020
End Date: July 31, 2021 (Estimated)
Total Intended Award Amount: $200,000.00
Total Awarded Amount to Date: $200,000.00
Funds Obligated to Date: FY 2020 = $200,000.00
History of Investigator:
  • Jiaxing Huang (Principal Investigator)
    jiaxing-huang@northwestern.edu
Recipient Sponsored Research Office: Northwestern University
633 CLARK ST
EVANSTON
IL  US  60208-0001
(312)503-7955
Sponsor Congressional District: 09
Primary Place of Performance: Northwestern University
2220 Campus Dr
Evanston
IL  US  60208-0893
Primary Place of Performance
Congressional District:
09
Unique Entity Identifier (UEI): EXZVPWZBLUE8
Parent UEI:
NSF Program(s): DMR SHORT TERM SUPPORT,
SOLID STATE & MATERIALS CHEMIS
Primary Program Source: 01002021DB NSF RESEARCH & RELATED ACTIVIT
Program Reference Code(s): 7237, 7573, 7914, 8614
Program Element Code(s): 171200, 176200
Award Agency Code: 4900
Fund Agency Code: 4900
Assistance Listing Number(s): 47.049

ABSTRACT

NON-TECHNICAL ABSTRACT:

Spread of infectious respiratory diseases, such as influenza, SARS, MERS, and COVID-19, usually starts from virion-laden respiratory droplets, which are released by an infected person during coughing or sneezing. Most of the droplets end up depositing on various surfaces such as doorknobs, tabletops, buttons, handrails, and touchscreens, turning them into potentially infectious objects. For infection to occur, these virions must remain active when they are picked up by another person, often through direct contact by hands, and then transferred to mouth, nose and eyes. Direct transport of virus-laden droplets and nuclei to the respiratory tract is also possible through inhaling within close proximity to the source. Therefore, to slow down or even prevent virus spread, it would be desirable to greatly reduce the number and activity of the virions in those just-released respiratory droplets. This RAPID award, which is supported by the Solid State and Materials Chemistry Program in the Division of Materials Research, explores chemical modulation strategies for deactivating virions in the respiratory fluid droplets passing through a medical mask. This can reduce the number of active virions at the very source of their spread pathways, the cough. The project also helps to seed an effort to rally researchers in physical sciences and engineering to study the problems, develop new hypotheses, create user-centered solutions and educate the general public, to address the many challenges associated with the transmission and spread of infectious respiratory diseases.

TECHNICAL ABSTRACT:

Facial masks are often required for patients to block and absorb large respiratory fluid droplets, and to reroute those smaller escaping droplets to reduce their forward travelling distance. It would be desirable to develop drop-in strategies to add anti-viral functions to the disposable masks used by patients. This RAPID project, which is supported by the Solid State and Materials Chemistry Program in the Division of Materials Research, develops such an on-mask, chemical modulation strategy that focuses on altering the chemical composition of the escaped respiratory droplets to deactivate virions. The starting model system is a chemical modifier based on a conducting polymer. The polymer is doped with chemical agents that are known to generate harsh micro-environment to deactivate virions. The dopants can readily dissolve in warm respiratory fluid droplets during exhalation, but they do not vaporize in the incoming stream of colder and drier air during inhalation. Such an on-mask chemical modulation strategy adds chemical sanitization function to common medical masks for reducing the viability of virions. Since this drop-in chemical modulation is applied at the very beginning of the chain events of virus transmission, it is effective for all potential transmission pathways. Additionally, through this award stronger connections between biological/medical research and physical sciences/engineering are established and serve to inspire new hypotheses, questions and ideas that drive innovations to address the challenges associated with the transmission and spread of infectious respiratory diseases. A significant effort of this RAPID project is used to achieve this goal, so that the physical sciences and engineering communities can be better informed, educated and prepared to work with biological and medical researchers to create solutions, and join them in the educational outreach activities for the general public.

This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

PUBLICATIONS PRODUCED AS A RESULT OF THIS RESEARCH

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Huang, Haiyue and Park, Hun and Liu, Yihan and Huang, Jiaxing "On-Mask Chemical Modulation of Respiratory Droplets" Matter , v.3 , 2020 https://doi.org/10.1016/j.matt.2020.10.012 Citation Details
Huang, Haiyue and Fan, Chunhai and Li, Min and Nie, Hua-Li and Wang, Fu-Bing and Wang, Hui and Wang, Ruilan and Xia, Jianbo and Zheng, Xin and Zuo, Xiaolei and Huang, Jiaxing "COVID-19: A Call for Physical Scientists and Engineers" ACS Nano , v.14 , 2020 https://doi.org/10.1021/acsnano.0c02618 Citation Details

PROJECT OUTCOMES REPORT

Disclaimer

This Project Outcomes Report for the General Public is displayed verbatim as submitted by the Principal Investigator (PI) for this award. Any opinions, findings, and conclusions or recommendations expressed in this Report are those of the PI and do not necessarily reflect the views of the National Science Foundation; NSF has not approved or endorsed its content.

This NSF RAPID grant managed by the Solid State and Materials Chemistry in Division of Materials Research has supported the self-transformation of the PI and his trainees from doing basic materials research in university labs to proactively addressing challenges associated with a major crisis in the society. It has given the team a sense of purposes during a difficult period of time.   

First, leveraging his former trainees? help, the PI?s team was able to connect to biomedical experts, frontline clinicians, and public health leaders in China, many of whom had direct work experience with covid-19, to analyze problems and brainstorm research needs for physical sciences and engineering in response to covid-19, aiming to strengthen public health responses. Together they published the first of its kind perspective article in ACS Nano [2020, 14, 3747?3754], educating the community about the basics and some common misunderstandings of the virus, and sharing a list of research needs and even research ideas to respond to the crisis. This was done when covid-19 first appeared to be far away from the US, and then became quickly overwhelming the healthcare system. It was also a time when medical experts within the reach of the PI first didn?t have direct experience with covid-19 but quickly became unavailable. This bold collaboration has produced a timely document that many have later found useful.

Encouraged by this initial publication, the PI?s team applied to qualify as essentially researchers at the university and started working on one of the research ideas ? on mask chemical modulation of respiratory droplets, when university campus was closed. They worked on site throughout the Illinois stay-home order, and eventually demonstrated the proof of concept of this idea, which aims to chemically modulation droplets escaping from face coverings, so that pathogens in the droplets can be inactivated. This has led to a highly visible publication in Matter. At a later stage of the grant, the team also demonstrated another proof of concept of self-charging fabrics based on household fibers that can potentially work as a make-shift air filters or mask materials. This has led to a manuscript under review in an open access journal. These findings add to the knowledge pool for developing new tools to enhance public health measures during an outbreak of infectious respiratory disease.  

The team?s effort has been closely followed by many media throughout this endeavor. By carefully delivering messages through various journalists, the team has helped to motivate many other researchers that would have been waiting at home. One example is the founding of a grass-root organization called AMPT Network - Advanced Material Future Preparedness Taskforce, advocating materials research to address crisis and problems in the society. The team also helped journalist to fact check for issues related to masks, droplets, and later vaccines to correct misunderstandings and combat misinformation. The PI has given many webinars to students in the Northwestern community, a few materials-related events and universities in India and Brazil.

The project has also given the participating students and trainees an unusual experience of intellectual growth. For example, one international graduate student was used as an example by University World News as an example of how US international students are poised to play a significant role in fostering international collaboration and coordination to respond to the COVID-19 pandemic. An undergraduate student was given an independent project, which started remotely using household materials at her home, continued in the labs after reopening and eventually led to her first author manuscript.

Perhaps the biggest impact of the award is to see possible out of impossible. Like what the team wrote in the ACS Nano perspective: The COVID-19 pandemic is the type of global challenge that transcends territorial, political, ideological, religious, cultural, and academic boundaries. Researchers in physical sciences and engineering should rally to study such challenges, to develop new hypotheses, to define new research problems, to create user-centered solutions, and to educate ourselves and the general public, so that we can better work with biological and medical researchers to address the many aspects of challenges associated with the transmission and spread of infectious respiratory diseases.

The grant has ended but the pandemic has not. We wish to see people continue to break the boundaries and work together to create solutions.


Last Modified: 08/06/2021
Modified by: Jiaxing Huang

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